> Quick Answer: Semaglutide targets only GLP-1 receptors and has 7+ years of real-world use. Tirzepatide targets both GLP-1 and GIP receptors (dual-agonist) and is newer with 3+ years of use. Both are weekly injections with similar side effects. Choose based on your goals, medical history, and provider recommendation.
Overview
If you're considering GLP-1 medication for weight loss, you've likely come across two main options: Semaglutide and Tirzepatide. Both are highly effective, but they work differently and may be better suited for different individuals.
How They Work
Semaglutide: Single-Target Approach
Semaglutide targets GLP-1 receptors only. It mimics the natural GLP-1 hormone your body produces after eating, but lasts much longer in your system.
Tirzepatide: Dual-Target Approach
Tirzepatide targets both GLP-1 and GIP (Glucose-dependent Insulinotropic Polypeptide) receptors. This dual mechanism may provide enhanced effects on appetite, metabolism, and fat storage.
Side-by-Side Comparison
| Factor | Semaglutide | Tirzepatide |
|---|---|---|
| Mechanism | GLP-1 only | GLP-1 + GIP |
| Dosing | Once weekly | Once weekly |
| Years of Use | 7+ years | 3+ years |
| Administration | Subcutaneous injection | Subcutaneous injection |
Common Side Effects
Both medications have similar side effect profiles, primarily gastrointestinal:
- Nausea (usually temporary)
- Diarrhea
- Vomiting
- Constipation
- Abdominal discomfort
These side effects typically improve as your body adjusts to the medication. Gradual dose titration helps minimize side effects.
Cost Comparison
Brand-Name Medications
Brand-name GLP-1 medications typically cost $1,000-$1,300/month without insurance.
Compounded Versions
At Fifty 410, we offer compounded versions at significantly lower prices:
- Compounded Semaglutide: Starting at $116/month
- Compounded Tirzepatide: Starting at $133/month
Which One Should You Choose?
Consider Semaglutide If:
- You prefer a medication with a longer real-world track record
- You want a well-established option
- Cost is a major factor
Consider Tirzepatide If:
- You want dual-receptor activation (GLP-1 + GIP)
- You've tried other treatments without desired results
- You want the newest available option
What Our Providers Recommend
Ultimately, the choice between semaglutide and tirzepatide should be made with your healthcare provider based on:
- Your weight loss goals
- Medical history
- Previous medication responses
- Personal preferences
- Budget considerations
Many patients start with semaglutide and switch to tirzepatide if they want additional weight loss, while others begin with tirzepatide for maximum effect.
Getting Started
Both medications are available through Fifty 410 as compounded formulations, personalized to your needs by FDA-registered 503A and 503B pharmacies.
Take our free assessment to find out which option might be right for you.
This article is for informational purposes only and does not constitute medical advice. Consult with a healthcare provider before starting any treatment. Compounded medications are not FDA-approved finished drug products.