Your GLP-1 Injection Schedule
Understanding your twice-weekly dosing schedule and how splitting your doses may lead to better results with fewer side effects.
Twice-Weekly Injection Schedule
Inject subcutaneously twice per week, with doses at least 3 days apart
Your 12-Week Dosing Plan
Your dose gradually increases over 12 weeks, allowing your body to adjust comfortably while building to your therapeutic dose.
Starting Phase
Weeks 1-4
Building Phase
Weeks 5-8
Maintenance Phase
Weeks 9-12
Potential Benefits of Split Dosing
Twice-weekly injections may offer advantages over traditional once-weekly dosing for some patients.
Steady Medication Levels
Splitting your dose into two weekly injections may help maintain more consistent medication levels in your body, potentially avoiding the peaks and valleys that can occur with once-weekly dosing.
Reduced Side Effects
Smaller, more frequent doses may be better tolerated. This approach may help minimize common GLP-1 side effects like nausea, as your body isn't processing a large dose all at once.
Enhanced Appetite Control
With medication levels staying more stable throughout the week, you may experience more consistent appetite suppression and blood sugar regulation between doses.
Smoother Transition Between Phases
The gradual dose escalation over 12 weeks may allow your body to adapt comfortably, potentially making it easier to increase to higher therapeutic doses with fewer adjustment issues.
Split Dose vs. Single Dose
See the difference between taking your weekly dose all at once versus splitting it into two smaller doses.
Once Weekly
One large dose may cause medication levels to spike then drop, which may lead to more noticeable side effects and inconsistent appetite control.
Twice Weekly (Your Plan)
Two smaller doses may maintain steadier medication levels throughout the week, which may result in better tolerability and more consistent effects.
Tips for Success
Choose consistent days for your injections (e.g., Monday and Thursday, or Tuesday and Friday) to make it easy to remember.
Rotate injection sites between your abdomen, thigh, or upper arm to prevent skin irritation.
Store your medication in the refrigerator and allow it to reach room temperature for a few minutes before injecting for more comfort.
Set reminders on your phone for injection days to help establish a routine.
Track your doses in a journal or app to monitor your progress through each phase.
Important Information
This dosing schedule has been prescribed by your healthcare provider based on your individual needs. Do not adjust your dose or frequency without consulting your provider. If you experience severe side effects, miss multiple doses, or have questions about your treatment, please contact your care team through the safety information page or reach out via the patient portal.
References
- Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. https://pubmed.ncbi.nlm.nih.gov/33567185/
- Jastreboff AM, et al. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022;387(3):205-216. https://pubmed.ncbi.nlm.nih.gov/35658024/
- Rubino DM, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138-150. https://pubmed.ncbi.nlm.nih.gov/35015037/
- FDA. Subcutaneous Injection Technique. FDA Drug Safety Communication. https://www.fda.gov/drugs/drug-safety-and-availability
- Kushner RF, et al. Semaglutide 2.4 mg for the Treatment of Obesity: Key Elements of the STEP Trials 1 to 5. Obesity (Silver Spring). 2020;28(6):1050-1061. https://pubmed.ncbi.nlm.nih.gov/32441473/