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How to Maximize Your GLP-1 Results with Diet and Exercise

By Fifty 410 Medical Team|January 1, 2024|9 min read

> Quick Answer: To maximize GLP-1 results: 1) Eat 0.8-1g protein per pound of body weight daily to preserve muscle. 2) Do resistance training 2-3x/week. 3) Walk 7,000-10,000 steps daily. 4) Drink 64+ oz water. 5) Sleep 7-9 hours. These lifestyle changes can increase weight loss by 30-50% compared to medication alone.

Optimizing Your GLP-1 Journey

While GLP-1 medications are highly effective on their own, combining them with strategic lifestyle changes can significantly enhance your results and help you maintain your weight loss long-term.

The Benefits of Combination Therapy

GLP-1 medications combined with lifestyle modification can produce:

  • Enhanced weight loss results
  • Better preservation of muscle mass
  • Improved cardiovascular fitness
  • Higher long-term maintenance rates

Nutrition: What to Eat on GLP-1 Medication

Priority #1: Protein

Why it matters:

  • Preserves muscle mass during weight loss
  • Keeps you feeling full longer
  • Supports metabolism
  • Aids recovery from exercise

How much: 0.8-1.0 grams per pound of body weight daily

Best sources:

  • Chicken, turkey, lean beef
  • Fish and seafood
  • Eggs and egg whites
  • Greek yogurt
  • Legumes and tofu
  • Protein shakes (as supplement)

Priority #2: Vegetables and Fiber

Why it matters:

  • Low calorie, high volume = satisfaction
  • Supports gut health
  • Prevents constipation (common side effect)
  • Rich in essential nutrients

Aim for: 5+ servings daily

Priority #3: Smart Carbohydrates

Choose:

  • Whole grains (quinoa, brown rice, oats)
  • Legumes (beans, lentils)
  • Starchy vegetables (sweet potatoes)

Limit:

  • Refined sugars
  • White bread and pasta
  • Sugary drinks

Priority #4: Healthy Fats

Include:

  • Avocados
  • Olive oil
  • Nuts and seeds
  • Fatty fish (salmon, mackerel)

Sample Daily Meal Plan

Breakfast:

  • Greek yogurt with berries and nuts
  • Or: Eggs with vegetables and whole grain toast

Lunch:

  • Grilled chicken salad with olive oil dressing
  • Or: Turkey and vegetable wrap

Dinner:

  • Salmon with roasted vegetables and quinoa
  • Or: Lean beef stir-fry with brown rice

Snacks (if hungry):

  • String cheese
  • Handful of almonds
  • Protein shake
  • Vegetables with hummus

Exercise: Building a Sustainable Routine

Resistance Training (Most Important)

Why it matters:

  • Preserves lean muscle mass
  • Boosts resting metabolism
  • Improves body composition
  • Enhances long-term results

Recommendation: 2-3 sessions per week

Getting started:

  • Bodyweight exercises (squats, push-ups, lunges)
  • Resistance bands
  • Light dumbbells
  • Gym machines

Focus on compound movements:

  • Squats/Leg press
  • Deadlifts/Hip hinges
  • Rows/Pull-downs
  • Push-ups/Chest press
  • Shoulder press

Cardiovascular Exercise

Benefits:

  • Burns additional calories
  • Improves heart health
  • Boosts mood and energy
  • Supports overall fitness

Recommendation: 150+ minutes per week of moderate activity

Easy options:

  • Walking (7,000-10,000 steps daily)
  • Swimming
  • Cycling
  • Elliptical
  • Dance classes

Daily Movement

Don't underestimate NEAT (Non-Exercise Activity Thermogenesis):

  • Take stairs instead of elevators
  • Park farther away
  • Standing desk or walking meetings
  • Household chores and gardening
  • Playing with kids or pets

Lifestyle Factors That Matter

Sleep

Why it matters:

  • Regulates hunger hormones
  • Supports recovery
  • Affects food choices
  • Influences metabolism

Aim for: 7-9 hours quality sleep nightly

Stress Management

Why it matters:

  • Cortisol promotes fat storage
  • Stress triggers emotional eating
  • Affects adherence to healthy habits

Strategies:

  • Regular exercise
  • Meditation or mindfulness
  • Deep breathing
  • Time in nature
  • Social connections

Hydration

Why it matters:

  • Supports medication effectiveness
  • Reduces false hunger signals
  • Helps with side effects
  • Essential for exercise

Aim for: 64+ oz water daily (more with exercise)

Common Mistakes to Avoid

  • Over-restricting calories - The medication naturally reduces intake; don't add extreme restriction
  • Skipping protein - This leads to muscle loss and worse long-term outcomes
  • Avoiding all carbs - Your body needs fuel, especially for exercise
  • Only doing cardio - Resistance training is crucial for body composition
  • Being too aggressive too fast - Build habits gradually for sustainability
  • Tracking Your Progress

    Measure more than just weight:

    • Body measurements (waist, hips, arms)
    • Progress photos monthly
    • How clothes fit
    • Energy levels
    • Fitness improvements
    • Blood markers (A1C, cholesterol, etc.)

    The Long Game

    Remember: The goal isn't just to lose weight, but to build a healthier lifestyle you can maintain. The habits you develop while on GLP-1 medication will serve you well whether you continue treatment or eventually transition off.

    Start your optimized weight loss journey


    Consult with a healthcare provider or registered dietitian for personalized nutrition and exercise recommendations. Compounded medications are not FDA-approved finished drug products.

    Topics:dietexerciseresultslifestyletips

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